central nervous system relapse in acute lymphoblastic leukemia (study on 160 cases)
نویسندگان
چکیده
from 1365 to 1382, 205 cases of acute lymphoblastic leukemia (all) were refered to our center. 160 cases achived complete remission and entered our clinical trial of cns relapse which were under consideration. the patients included 98 men and 62 women with an average age of 32 years (range 4-61 years). 160 of 205 cases had complete remission with a rate about 78%.the latter group was entered into our clinical trial. the patients were followed for 30 months after starting maintenance therapy. all patients underwent cns prophelaxy by cns irradiation with 14 gy and intratechal methotrexate in jection for 6 weeks. 24 cases had relapsed. the age of cns relapsed patients were between 9 to 58 years (mean 31y). patient sex: 11 male of 91, 13 female of 69. results: 1 case showed cns relapse after 4 months of starting maitenance therapy. 19 cases relapsed in the duration of 6-18 months after starting maintenance therapy. 2 cases relapsed within 24 & 28 months after starting maintenance therapy. the statistic analysis are summarized as follows: 1-cns relapse of allin the females are more than males (p=0.001). 2-cns relapse of all in the age groupe older than 12 years were higher. 3-cns relapse of all in those patients with bone marrow failure in responding to first period of treatment were higher (p=0.002). 4-cns relapse of all in those patients with leukocytosis more than 40.000/ul were higher (p=0.003). 5-the first symptom of cns relapse was severe headache (100%). 6-cns relapse of all were in 18 months period of strating maintenance therapy. 7-cns relapse of all in those patients with type ii all were more than type i, with a rate of 18.7 % and 4.7% respectively.
منابع مشابه
Isolated Central Nervous System Relapse of Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer and may exhibit central nervous system (CNS) involvement. Advances in chemotherapy and effective CNS prophylaxis have significantly decreased the incidence of CNS relapse of ALL to 5-10%. Here, we report the case of a patient with isolated CNS relapse of standard risk group pre-B-cell type ALL in an 11-year-old girl,...
متن کاملCentral nervous system relapse prophylaxis in acute lymphoblastic leukemia (ALL) intrathecal chemotherapy with and without cranial irradiation
Background: Central Nervous System (CNS) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, Intrathecal chemotherapy and cranial irradiation. The purpose of this study was to compare the effectiveness of intrathecal (IT) CNS chemotherapy alone versus combination of IT chemotherapy with cranial irradiation for prevention of CNS rel...
متن کاملHydrocephalus as Clinical Indicator of Central Nervous System Relapse in Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosis in children. While current treatment has greatly improved survival rates, relapse occurs in 15-20% of patients. Signs and symptoms are similar to those found at initial presentation. However, in some patients, relapse can occur in the central nervous system (CNS), even if they did not have previous CNS involvement. Many case...
متن کاملThe role of supine and prone positions on central nervous system involvement in patients with acute lymphoblastic leukemia
Background: Acute lymphoblastic leukemia (ALL) affects both children and adults, with a peak incidence between the ages of 2 and 5 years. ALL cells sometimes penetrate the central nervous system (CNS) and patients with CNS diseases at initial presentation have been reported to experience a significantly greater risk of treatment failure compared with CNS negative patients. This study hypothesiz...
متن کاملcentral nervous system relapse prophylaxis in acute lymphoblastic leukemia (all) intrathecal chemotherapy with and without cranial irradiation
background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...
متن کاملLeukemia Cutis in a Child with Acute Lymphoblastic Leukemia at Diagnosis and Relapse
این مقاله فاقد چکیده میباشد.
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
international journal of hematology-oncology and stem cell researchجلد ۲، شماره ۲، صفحات ۱۶-۲۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023